The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Ī universal feature of eukaryotic cells is that the nuclear size appears to be correlated with the cell size. DAW and AFP are supported by NIH P01HL120839 and Harvard Materials Research Science and Engineering Center Grant DMR-1420570. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting information files.įunding: SXS and YFW are supported by NIH R01GM134542. Received: AugAccepted: JanuPublished: February 18, 2022Ĭopyright: © 2022 Wu et al. Finally, although not explicitly demonstrated in this work, we point out that it is possible to construct a detailed proteome distribution using our model and RNAseq data, provided that a quantitative cell division mechanism is known.Ĭitation: Wu Y, Pegoraro AF, Weitz DA, Janmey P, Sun SX (2022) The correlation between cell and nucleus size is explained by an eukaryotic cell growth model. We find that in order to regulate the cell growth rate and the cell/nucleus volume ratio, the cell must optimally control groups of kinetic and transport parameters together, which could explain the quantitative roles of canonical growth pathways. Ribosome assembly and the ratio of ribosomal proteins to mature ribosomes also influence the cell volume and the cell growth rate. Results show that the cell volume is tightly correlated with the nuclear volume, and the cytoplasm-nucleoplasm transport rates strongly influence the cell growth rate as well as the cell/nucleus volume ratio (C/N ratio). We also include a simple model of ribosome biogenesis and assembly. We develop a computational model of cell growth and proteome increase, incorporating the kinetics of amino acid import, protein/ribosome synthesis and degradation, and active transport of proteins between the cytoplasm and the nucleoplasm. The slope of this correlation depends on the cell type, growth condition, and the physical environment of the cell. In eukaryotes, the cell volume is observed to be strongly correlated with the nuclear volume.
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